In the vast realm of Ayurveda, a holistic system of medicine, there exists a lesser-known but powerful concept called Arthāpatti Pramana. Often regarded as the fifth Pramana, or means of valid knowledge, by commentators of the Mimamsa Darshana, Arthāpatti Pramana holds the key to understanding the enigmatic and unexplained aspects of Ayurvedic principles. While renowned ancient physicians like Charaka and Sushruta did not explicitly recognize it as a Pramana, its significance finds mention in the Vimana-sthana of Charaka. Throughout this blog, we will delve into the definition, types, and enduring importance of Arthāpatti Pramana within the realm of Ayurveda.